face c-src elisa kit Search Results


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Carna Inc recombinant fgfr1
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
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Bio-Rad c src levels
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
C Src Levels, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Abnova c-src kinase activity assay kit
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
C Src Kinase Activity Assay Kit, supplied by Abnova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Carna Inc source protein kinase b akt1 catalytic domain 01 401 20n carna biosciences
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
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Santa Cruz Biotechnology c src
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
C Src, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Federation of European Neuroscience Societies csrd (yhda)
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
Csrd (Yhda), supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Carna Inc trka invitrogen cat
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
Trka Invitrogen Cat, supplied by Carna Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Carna Inc wt egfr
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
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Cell Signaling Technology Inc phosphoplus c src antibody kits
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
Phosphoplus C Src Antibody Kits, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cytoskeleton Inc principal c src rac1 cytoskeleton
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
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Proteintech pan c src
(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with <t>FGFR1</t> and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.
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Image Search Results


(A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with FGFR1 and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.

Journal: PLoS ONE

Article Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

doi: 10.1371/journal.pone.0162594

Figure Lengend Snippet: (A) ARQ 069. (B) ARQ 087. (C) Enzyme kinetic analysis was performed to determine the mode of inhibition of ARQ 087 with FGFR1 and FGFR2. Concentrations of ATP [ATP] and ARQ 087 [I] are indicated on the graphs. The rate plotted is the AlphaScreen ™ signal obtained from the plate reader with background correction. The experiments were conducted in triplicates and the means and the standard deviations were plotted. The number of parameter ( n p ), the sum of squares rel ( SS rel ), Akaike information criterion ( AIC ), weight of AIC ( w (AIC) ), Bayesian information criterion ( BIC ) and the weight of BIC ( w (BIC) ) for each binding mode were determined by the DynaFit software and are summarized below the plots. The dissociation constant ( K i) of ARQ 087 for FGFR1 and FGFR2 are shown. (D) The effect of ARQ 087 on the activation of FGFR1 and FGFR2 was examined in a continuous autophosphorylation assay.

Article Snippet: Kinase inhibitory activity of ARQ 087 was determined for the recombinant FGFR1 (Cat#08133, Carna BioScience, Kobe, Japan) or FGFR2 proteins (Cat#08134, Carna BioScience, Kobe, Japan), utilizing a biotinylated PYK2 peptide substrate (biotin-AGAGSIESDIYAEIPDETC-NH2, Biopeptide, San Diego, CA), and ATP (Cat#12215226, Roche, Indianapolis, IN), with AlphaScreen ™ technology (PerkinElmer, Waltham, MA).

Techniques: Inhibition, Amplified Luminescent Proximity Homogenous Assay, Binding Assay, Software, Activation Assay

ARQ 087 biochemical activity.

Journal: PLoS ONE

Article Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

doi: 10.1371/journal.pone.0162594

Figure Lengend Snippet: ARQ 087 biochemical activity.

Article Snippet: Kinase inhibitory activity of ARQ 087 was determined for the recombinant FGFR1 (Cat#08133, Carna BioScience, Kobe, Japan) or FGFR2 proteins (Cat#08134, Carna BioScience, Kobe, Japan), utilizing a biotinylated PYK2 peptide substrate (biotin-AGAGSIESDIYAEIPDETC-NH2, Biopeptide, San Diego, CA), and ATP (Cat#12215226, Roche, Indianapolis, IN), with AlphaScreen ™ technology (PerkinElmer, Waltham, MA).

Techniques: Activity Assay

COS-1 cells ectopically expressing FGFR1, FGFR2, FGFR3 or FGFR4 were treated with the indicated concentrations of ARQ 087 for 2 hours followed by stimulation with 100 pM of FGF1/2/7 for 15 minutes. Total and phospho-FGFR was assessed by Western blot analyses. β-Actin was used as a loading control. The EC 50 values of individual FGFR family members are shown.

Journal: PLoS ONE

Article Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

doi: 10.1371/journal.pone.0162594

Figure Lengend Snippet: COS-1 cells ectopically expressing FGFR1, FGFR2, FGFR3 or FGFR4 were treated with the indicated concentrations of ARQ 087 for 2 hours followed by stimulation with 100 pM of FGF1/2/7 for 15 minutes. Total and phospho-FGFR was assessed by Western blot analyses. β-Actin was used as a loading control. The EC 50 values of individual FGFR family members are shown.

Article Snippet: Kinase inhibitory activity of ARQ 087 was determined for the recombinant FGFR1 (Cat#08133, Carna BioScience, Kobe, Japan) or FGFR2 proteins (Cat#08134, Carna BioScience, Kobe, Japan), utilizing a biotinylated PYK2 peptide substrate (biotin-AGAGSIESDIYAEIPDETC-NH2, Biopeptide, San Diego, CA), and ATP (Cat#12215226, Roche, Indianapolis, IN), with AlphaScreen ™ technology (PerkinElmer, Waltham, MA).

Techniques: Expressing, Western Blot

ARQ 087 GI 50 in Ba/F3 transfected cell lines.

Journal: PLoS ONE

Article Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

doi: 10.1371/journal.pone.0162594

Figure Lengend Snippet: ARQ 087 GI 50 in Ba/F3 transfected cell lines.

Article Snippet: Kinase inhibitory activity of ARQ 087 was determined for the recombinant FGFR1 (Cat#08133, Carna BioScience, Kobe, Japan) or FGFR2 proteins (Cat#08134, Carna BioScience, Kobe, Japan), utilizing a biotinylated PYK2 peptide substrate (biotin-AGAGSIESDIYAEIPDETC-NH2, Biopeptide, San Diego, CA), and ATP (Cat#12215226, Roche, Indianapolis, IN), with AlphaScreen ™ technology (PerkinElmer, Waltham, MA).

Techniques: Transfection

ARQ 087 activity in FGFR dysregulated cell lines.

Journal: PLoS ONE

Article Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

doi: 10.1371/journal.pone.0162594

Figure Lengend Snippet: ARQ 087 activity in FGFR dysregulated cell lines.

Article Snippet: Kinase inhibitory activity of ARQ 087 was determined for the recombinant FGFR1 (Cat#08133, Carna BioScience, Kobe, Japan) or FGFR2 proteins (Cat#08134, Carna BioScience, Kobe, Japan), utilizing a biotinylated PYK2 peptide substrate (biotin-AGAGSIESDIYAEIPDETC-NH2, Biopeptide, San Diego, CA), and ATP (Cat#12215226, Roche, Indianapolis, IN), with AlphaScreen ™ technology (PerkinElmer, Waltham, MA).

Techniques: Activity Assay, Amplification, Over Expression